2, sodium bicarbonate and sodium carbonate), lactose monohydrate, magnesium stearate, and pregelatinized corn starch, Blue pill: anhydrous lactose, FD&C blue no. However, this may be due to other reasons such as having more sexual partners. Use non-hormonal contraception when you stop taking Tri-Sprintec. Adverse Reactions Leading to Study Discontinuation: Over the trials, between 9 to 27% of subjects discontinued the trial due to an adverse reaction. INDICATIONS. Do not start until 4 weeks after a second-trimester abortion or miscarriage, due to the increased risk of thromboembolic disease. Additional non-hormonal contraception (such as condoms and spermicide) should be used as back-up if the patient has sex within 7 days after missing tablets. Take the pills in each new package as before. Start taking Tri-Sprintec on the day of removal of your IUD or IUS. After a first-trimester abortion or miscarriage, Tri-Sprintec may be started immediately. Stop Tri-Sprintec if an arterial thrombotic event or venous thromboembolic (VTE) event occurs. had breast cancer or any cancer that is sensitive to female hormones, are pregnant or think you may be pregnant, are depressed now or have been depressed in the past, had yellowing of your skin or eyes (jaundice) caused by pregnancy (cholestasis of pregnancy). (norgestimate and ethinyl estradiol tablets). The risk of postpartum VTE decreases after the third postpartum week, whereas the risk of ovulation increases after the third postpartum week. Do not administer COCs to induce withdrawal bleeding as a test for pregnancy. What should I tell my healthcare provider before taking Tri-Sprintec? Steady-state concentration of EE is achieved by Day 7 of each dosing cycle. If you are scheduled for any lab tests, tell your healthcare provider you are taking Tri-Lo-Sprintec. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Your healthcare provider should tell you when to start taking your birth control pill. These include 18, 19-Dinor-17-pregn-4-en-20-yn-3-one,17-hydroxy-13-ethyl,(17α)-(-);18,19-Dinor-5β‑17-pregnan-20-yn,3α,17β-dihydroxy-13-ethyl,(17α), various hydroxylated metabolites and conjugates of these metabolites. Studies also do not suggest a teratogenic effect, particularly in so far as cardiac anomalies and limb reduction defects are concerned, when oral contraceptives are taken inadvertently during early pregnancy. [See Contraindications (4) and Warnings and Precautions (5.2).]. Consider discontinuation of Tri-Lo-Sprintec in the case of increased frequency or severity of migraine during COC use (which may be prodromal of a cerebrovascular event). We comply with the HONcode standard for trustworthy health information. In women with hereditary angioedema, exogenous estrogens may induce or exacerbate symptoms of angioedema. Active ingredients: Each gray, light blue, and blue pill contains norgestimate and ethinyl estradiol. The risk of thromboembolic disease due to COCs gradually disappears after use is discontinued. Tri-Sprintec® (norgestimate and ethinyl estradiol tablets USP) is a combination oral contraceptive containing the progestational compound norgestimate, USP and the estrogenic compound ethinyl estradiol, USP. Start with the gray pill on row #1 and take one pill each day, left to right, until the last white pill has been taken. are breastfeeding or plan to breastfeed. Tri-Sprintec does not protect against HIV infection (AIDS) and other sexually transmitted infections. Certain blood tests may be affected by Tri-Sprintec. You may feel sick to your stomach (nauseous), especially during the first few months of taking Tri-Sprintec. This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked. Safety and efficacy of Tri-Lo-Sprintec tablets have been established in women of reproductive age. (This is the day you begin bleeding or spotting, even if it is midnight when bleeding begins.) The effect of food on the pharmacokinetics of Tri-Sprintec has not been studied. EE is also metabolized to various hydroxylated products and their glucuronide and sulfate conjugates. If scheduled (withdrawal) bleeding does not occur, consider the possibility of pregnancy. swelling of your skin especially around your mouth, eyes, and in your throat (angioedema). If your IUD or IUS is removed on any other day, use non-hormonal back-up contraception such as condoms and spermicide for the first, If your period starts on a Sunday, take pill “, Use non-hormonal back-up contraception such as condoms and spermicide for the first, Take it as soon as you remember. Counsel patients about the following information: Tri-Sprintec® [trī- sprin-tek] Consider the possibility of ovulation and conception prior to initiation of this product. Switching to Tri-Sprintec from another oral contraceptive. Substances increasing the plasma concentrations of COCs: Co-administration of atorvastatin or rosuvastatin and certain COCs containing ethinyl estradiol (EE) increase AUC values for EE by approximately 20 to 25%. Tri-Sprintec can be restarted approximately 2 weeks following completion of treatment with the Hepatitis C combination drug regimen. Contact your healthcare provider if this does not go away after a few months. If the IUD is not removed on first day of the patient’s menstrual cycle, additional non-hormonal contraceptive (such as condoms and spermicide) is needed for the first seven days of the first cycle pack. Tri-Sprintec may affect the way other medicines work, and other medicines may affect how well Tri-Sprintec works. Tri-Sprintec may be started using either a Day 1 start or a Sunday start (see Table 1). If the woman has not yet had a period postpartum, consider the possibility of ovulation and conception occurring prior to use of Tri-Sprintec. Efficacy is expected to be the same for post‑pubertal adolescents under the age of 18 and for users 18 years and older. There was no significant difference between Tri-Sprintec tablets and placebo in mean change in total lumbar spine (L1-L4) and total hip bone mineral density between baseline and Cycle 13 in 123 adolescent females with anorexia nervosa in a double-blind, placebo-controlled, multicenter, one-year treatment duration clinical trial for the Intent To Treat (ITT) population. No specific pharmacodynamic studies were conducted with Tri-Sprintec. The most common adverse reactions (≥1%) leading to discontinuation were: metrorrhagia (4.3%), nausea/vomiting (2.8%), headache/migraine (2.4%), mood disorders (including depression and mood altered) (1.1%), and weight increased (1.1%). Active ingredients: Each gray pill contains 0.18 mg norgestimate and 0.035 mg ethinyl estradiol. However, if you miss a period and have not taken Tri-Lo-Sprintec according to directions, or miss. Tri-Sprintec is also used to treat moderate acne vulgaris in females 15 years of age and older, who have no known history of allergies or problems taking birth control pills, and have started their menstrual cycle (“period”). Call your healthcare provider if you have yellowing of your skin or eyes. Peak serum concentrations of NGMN and EE were generally reached by 2 hours after administration of Tri-Lo-Sprintec. This may increase levels of the liver enzyme “alanine aminotransferase” (ALT) in the blood. Discontinue Tri-Sprintec prior to starting therapy with the combination drug regimen ombitasvir/paritaprevir/ritonavir, with or without dasabuvir [see Contraindications (4)]. However, steroid hormones may be poorly metabolized in patients with hepatic impairment. Tell your healthcare provider about all the medicines you take. The pharmacokinetics of Tri-Lo-Sprintec has not been studied in women with renal impairment. If pathology and pregnancy are excluded, bleeding irregularities may resolve over time or with a change to a different contraceptive product. The box on the bottom of the chart shows the chance of getting pregnant for women who do not use birth control and are trying to get pregnant. Start Tri-Sprintec, following the instructions in Table 1 for Day 1 or Sunday start, as desired. Follow the sticker with the days of the week (placed above the pills). If you start taking Tri-Sprintec andyou have not used a hormonal birth control method before: If you start taking Tri-Sprintec and you are switching from another birth control pill: If you start taking Tri-Sprintec and previously used a vaginal ring or transdermal patch: If you start taking Tri-Sprintec and you are switching from a progestin-only method such as an implant or injection: If you start taking Tri-Sprintec andyou are switching from an intrauterine device or system (IUD or IUS): If this is the first time you are taking birth control pills, read, “When should I start taking Tri-Sprintec?” above. Start contraceptive therapy with Tri-Sprintec following the instructions in Table 1 for women not currently using hormonal contraception. Increasing age was associated with slight decreases (6% with increasing age by 5 years) in Cmax and AUC0-24h for NGMN and were statistically significant, but there was no significant effect for NG or EE. If Tri-Lo-Sprintec is not started within 5 days after termination of the pregnancy, the patient should use additional non-hormonal contraception (such as condoms and spermicide) for the first seven days of her first cycle pack of Tri-Lo-Sprintec. Do not give Tri-Sprintec to other people, even if they have the same symptoms that you have. Serious blood clots are more likely to happen when you: Call your healthcare provider or go to a hospital emergency room right away if you have: What are the most common side effects of Tri-Sprintec? Based on data from the clinical trials, 7 to 17% of women using norgestimate and ethinyl estradiol experienced unscheduled bleeding per cycle in the first year. Due to the potential risk of becoming pregnant, use additional non-hormonal contraception (such as condoms and spermicide) for the first seven days of the patient’s first cycle pack of Tri-Lo-Sprintec. Overdosage may cause withdrawal bleeding in females and nausea. Some women may experience amenorrhea or oligomenorrhea after discontinuation of COCs, especially when such a condition was pre-existent. There were no exclusions on the basis of weight; the weight range for women treated was 80 to 310 lbs, with a mean weight of about 132 lbs. Tri-Lo-Sprintec may affect the way other medicines work, and other medicines may affect how well Tri-Lo-Sprintec works. Medically reviewed by Drugs.com. When should I start taking Tri-Lo-Sprintec? There are two ways to start taking birth control pills, Sunday Start or Day 1 Start. The dose of replacement thyroid hormone or cortisol therapy may need to be increased. Your periods may be lighter and shorter than usual. You do not need back-up contraception if your IUD or IUS is removed on the first day (Day 1) of your period. Tri-Lo-Sprintec may be started using either a Day 1 start or a Sunday start (see Table 1). changes in the sugar and fat (cholesterol and triglycerides) levels in your blood, new or worsening headaches including migraine headaches. Missing pills can also cause spotting or light bleeding, even when you take the missed pills later. Note that the pills are arranged in four numbered rows of 7 pills, with the pre-printed days of the week printed above them. Our medical team will work with you to find the best anxiety medication for your unique situation and we’ll monitor your dose to make sure it’s delivering the relief you need. Significant decrease in plasma concentration of lamotrigine has been shown, likely due to induction of lamotrigine glucuronidation. Ascorbic acid and acetaminophen may increase plasma EE concentrations, possibly by inhibition of conjugation. A woman who is taking COCs should have a yearly visit with her healthcare provider for a blood pressure check and for other indicated healthcare. Mean (SD) Pharmacokinetic Parameters of Tri-Sprintec During a Three Cycle Study. Discontinue Tri-Lo-Sprintec use if pregnancy is confirmed. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Note that the pills are arranged in four numbered rows of 7 pills, with the pre-printed days of the week printed above them. Combined Results: Two Multicenter, Placebo-Controlled Trials. You do not need back-up contraception if your IUD or IUS is removed on the first day (Day 1) of your period. The pharmacokinetics of NGMN is dose-proportional following NGM doses of 180 mcg to 250 mcg. During clinical trials with the Hepatitis C combination drug regimen that contains ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, ALT elevations greater than 5 times the upper limit of normal (ULN), including some cases greater than 20 times the ULN, were significantly more frequent in women using ethinyl estradiol-containing medications, such as COCs. Take first active tablet without regard to meals on the first day of menses. Based on data from the clinical trials, 13 to 38% of women using norgestimate and ethinyl estradiol experienced unscheduled bleeding per cycle in the first year. Do not skip your pills, even if you do not have sex often. Subjects were followed for up to 13 28-day cycles. Serious Adverse Reactions: breast cancer (1 subject), carcinoma of the cervix in situ (1 subject), hypertension (1 subject), and migraine (2 subjects). Studies suggest a small increased relative risk of developing gallbladder disease among COC users. However, if you have breast cancer now, or have had it in the past, do not use birth control pills because some breast cancers are sensitive to hormones. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you are scheduled for any lab tests, tell your healthcare provider you are taking Tri-Sprintec. Tri-Sprintec (norgestimate and ethinyl estradiol tablets) is indicated for the treatment of moderate acne vulgaris in females at least 15 years of age, who have no known contraindications to oral contraceptive therapy and have achieved menarche. Accumulation following multiple dosing of the 250 mcg NGM / 35 mcg EE dose is approximately 2-fold for NGMN and EE compared with single dose administration. Combined Results: Two Multicenter, Placebo-Controlled Trials. NGMN and NG: Cmax = ng/mL, AUC0-24h = h•ng/mL. Generic Name: norgestimate and ethinyl estradiol Additional non-hormonal contraception (such as condoms and spermicide) should be used as back‑up if the patient has sex within 7 days after missing tablets. Acute or chronic disturbances of liver function may necessitate the discontinuation of COC use until markers of liver function return to normal and COC causation has been excluded. Take the 2 missed pills as soon as possible and the next 2 pills the next day. possible cancer in your breast and cervix. Each white tablet contains only inert ingredients, as follows: anhydrous lactose, hypromellose, magnesium stearate, and microcrystalline cellulose. Read the Instructions for Use at the end of this Patient Information. Accumulation following multiple dosing of the 0.180 mg NGM / 0.025 mg EE dose is approximately 1.5 to 2 fold for NGMN and approximately 1.5 fold for EE compared with single dose administration, in agreement with that predicted based on linear kinetics of NGMN and EE. Each white tablet contains only inert ingredients as follows: anhydrous lactose, hypromellose, magnesium stearate, and microcrystalline cellulose. However, pregnancy increases the risk of VTE as much or more than the use of COCs. If one active tablet is missed in Weeks 1, 2, or 3, If two active tablets are missed in Week 1 or Week 2, If two active tablets are missed in the third week or three or more active tablets are missed in a row in Weeks 1, 2, or 3, 7 gray round, film-coated, biconvex, unscored tablets, debossed with stylized b on one side and 451 on the other side contains 0.18 mg of the progestational compound, norgestimate together with 0.025 mg of the estrogenic compound, ethinyl estradiol, 7 light blue, round, film-coated, biconvex, unscored tablets, debossed with stylized b on one side and 452 on the other side contains 0.215 mg of the progestational compound, norgestimate together with 0.025 mg of the estrogenic compound, ethinyl estradiol, 7 blue, round, film-coated, biconvex, unscored tablets, debossed with stylized b on one side and 453 on the other side contains 0.25 mg of the progestational compound, norgestimate together with 0.025 mg of the estrogenic compound, ethinyl estradiol, 7 white, round, biconvex, unscored, placebo tablets, debossed with stylized b on one side and 208 on the other side contains inert ingredients. Table 3: Summary of NGMN, NG and EE pharmacokinetic parameters. Human immunodeficiency virus (HIV)/Hepatitis C virus (HCV) protease inhibitors and non-nucleoside reverse transcriptase inhibitors: Significant changes (increase or decrease) in the plasma concentrations of estrogen and/or progestin have been noted in some cases of co-administration with HIV protease inhibitors (decrease [e.g., nelfinavir, ritonavir, darunavir/ritonavir, (fos)amprenavir/ritonavir, lopinavir/ritonavir, and tipranavir/ritonavir] or increase [e.g., indinavir and atazanavir/ritonavir])/HCV protease inhibitors (decrease [e.g., boceprevir and telaprevir]) or with non-nucleoside reverse transcriptase inhibitors (decrease [e.g., nevirapine] or increase [e.g., etravirine]). Refer to the sample of the blister card below: After taking the last white pill, start a new blister card the. Contact your healthcare provider if this does not go away after a few months. The pharmacokinetics of Tri-Lo-Sprintec has not been studied in subjects with hepatic impairment. Following 3 cycles of administration of Tri-Lo-Sprintec, the mean (± SD) elimination half-life values, at steady-state, for NGMN, NG and EE were 28.1 (± 10.6) hours, 36.4 (± 10.2) hours and 17.7 (± 4.4) hours, respectively (Table 2). Some drugs or herbal products that may decrease the effectiveness of COCs include phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, topiramate, rifabutin, rufinamide, aprepitant and products containing St. John’s wort. Some women may miss a period. The problem will usually go away. Efficacy is expected to be the same for post-pubertal adolescents under the age of 18 and for users 18 years and older. Women who use Tri-Sprintec may experience amenorrhea. Start on the same day that a new pack of the. Although NGMN and its metabolites inhibit a variety of P450 enzymes in human liver microsomes, under the recommended dosing regimen, the in vivo concentrations of NGMN and its metabolites, even at the peak serum levels, are relatively low compared to the inhibitory constant (Ki). Each light blue tablet contains 0.215 mg of the progestational compound norgestimate, USP (18,19-Dinor-17-pregn-4-en-20-yn-3-one,17-(acetyloxy)-13-ethyl-, oxime, (17α)-(+)-) and 0.035 mg of the estrogenic compound, ethinyl estradiol, USP (19-Nor-17α-pregna,1,3,5(10)-trien-20-yne-3, 17-diol), and the inactive ingredients include anhydrous lactose, FD&C blue no. The most effective methods are at the top of the chart. Tri-Sprinteccomes in a blister pack tablet dispenser. Know the medicines you take. previous oral contraceptive would have started. If any of these conditions happen while you are taking Tri-Lo-Sprintec, stop taking Tri-Lo-Sprintec right away and talk to your healthcare provider. Starting Tri-Sprintec after Abortion or Miscarriage. When you have picked the right sticker, throw away the others and place the sticker on the blister card over the pre-printed days of the week and make sure it lines up with the pills. Substances decreasing the plasma concentrations of COCs: Drugs or herbal products that induce certain enzymes, including cytochrome P450 3A4 (CYP3A4), may decrease the plasma concentrations of COCs and potentially diminish the effectiveness of COCs or increase breakthrough bleeding. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. Do not use COCs during pregnancy to treat threatened or habitual abortion. Like pregnancy, Tri-Lo-Sprintec may cause serious side effects, including blood clots in your lungs, heart attack, or a stroke that may lead to death. Cysts and Polyps), Respiratory, Thoracic and Mediastinal Disorders, Musculoskeletal, Connective Tissue, and Bone Disorders, General Disorders and Administration Site Conditions, Table 4: Acne Vulgaris Indication. Each box on the chart contains a list of birth control methods that are similar in effectiveness. COCs lower the risk of becoming pregnant primarily by suppressing ovulation. NGM is extensively metabolized by first-pass mechanisms in the gastrointestinal tract and/or liver. Start your new Tri-Sprintec pack on the same day that you would start the next pack of your previous birth control method. Table 3: Mean (SD) Pharmacokinetic Parameters of Tri-Lo-Sprintec During a Three Cycle Study. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Start using Tri-Sprintec on the day you would have reapplied the next ring or patch. However, if you have breast cancer now, or have had it in the past, do not use birth control pills because some breast cancers are sensitive to hormones. In case of severe vomiting or diarrhea, absorption may not be complete and additional contraceptive measures should be taken. If the patient has not adhered to the prescribed dosing schedule (missed one or more active tablets or started taking them on a day later than she should have), consider the possibility of pregnancy at the time of the first missed period and take appropriate diagnostic measures. breast pain or tenderness, enlargement or discharge. EE is extensively bound (>97%) to serum albumin and induces an increase in the serum concentrations of SHBG. For this reason, COCs are contraindicated in women who are over 35 years of age and smoke. Intent-to-Treat Population. Use COCs with caution in women with cardiovascular disease risk factors. NGMN is bound to albumin and not to SHBG, while NG is bound primarily to SHBG. Instruct patients what to do in the event tablets are missed, Use a back-up or alternative method of contraception when enzyme inducers are used with Tri-Lo-Sprintec, COCs may reduce breast milk production, this is less likely to occur if breastfeeding is well established, Women who start COCs postpartum; and who have not yet had a period, should use an additional method of contraception until they have taken a gray tablet for 7 consecutive days, Amenorrhea may occur. Cmax = peak serum concentration, tmax = time to reach peak serum concentration, AUC0-24h = area under serum concentration vs time curve from 0 to 24 hours, t1/2 = elimination half-life, NC = not calculated. 2, FD&C red no. Day 1 start: Throw out the rest of the pack and start a new pack that same day. Adverse Reactions Leading to Study Discontinuation: Neoplasms Benign, Malignant and Unspecified (Incl. Do not co-administer Tri-Sprintec with HCV drug combinations containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, due to potential for ALT elevations [see Warnings and Precautions (5.3)]. Take subsequent active tablets once daily at the same time each day for a total of 21 days. Norgestimate, USP is designated as (18,19-Dinor-17-pregn-4-en-20-yn-3-one,17-(acetyloxy)-13-ethyl-, oxime,(17α)‑ (+)-) and ethinyl estradiol, USP is designated as (19-nor-17α-pregna,1,3,5(10)-trien-20-yne-3,17-diol). Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. See FDA-approved patient labeling (Patient Information and Instructions for Use). Table 1: Instructions for Administration of Tri-Lo-Sprintec, Starting COCs in women not currently using, hormonal contraception (Day 1 Start or Sunday Start). This trial examined healthy, nonpregnant, volunteers aged 18 to 45 (nonsmoker if 35 to 45 years of age), who were sexually active with regular coitus. The risk of VTE is highest during the first year of use of COCs and when restarting hormonal contraception after a break of 4 weeks or longer. If using Sunday start, use additional non-hormonal contraception (such as condoms and spermicide) for the first seven days of the patient’s first cycle pack of Tri-Lo-Sprintec. Do not use Tri-Sprintec if you smoke cigarettes and are over 35 years old. 2 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80 and titanium dioxide. Consider discontinuation of Tri-Sprintec in the case of increased frequency or severity of migraine during COC use (which may be prodromal of a cerebrovascular event). During clinical trials with the Hepatitis C combination drug regimen that contains ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, ALT elevations greater than 5 times the upper limit of normal (ULN), including some cases greater than 20 times the ULN, were significantly more frequent in women using ethinyl estradiol-containing medications, such as COCs. Rule out pregnancy in the event of amenorrhea in two or more consecutive cycles, had blood clots in your arms, legs, lungs, or eyes, had a problem with your blood that makes it clot more than normal, have certain heart valve problems or irregular heart beat that increases your risk of having blood clots, have high blood pressure that cannot be controlled by medicine, have diabetes with kidney, eye, nerve, or blood vessel damage, have certain kinds of severe migraine headaches with aura, numbness, weakness or changes in vision, or any migraine headaches if you are over 35 years of age, have liver problems, including liver tumors. The following serious adverse reactions with the use of COCs are discussed elsewhere in labeling: Adverse reactions commonly reported by COC users are: Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice. What else should I know about taking Tri-Sprintec? The use of COCs increases the risk of VTE. (norgestimate and Tri-Sprintec® (norgestimate and ethinyl estradiol tablets USP) is packaged in cartons of six blister cards. Non-linear accumulation (4.5 to 14.5 fold) of NG was observed as a result of high affinity binding to SHBG, which limits its biological activity. The racial demographic of those treated with Tri-Lo-Sprintec was: Caucasian (86%), African-American (6%), Asian (2%), and Other (6%). 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Reproductive age adjustments of lamotrigine has been associated with an increase in the tract... ) Protease inhibitors and Non-nucleoside Reverse Transcriptase inhibitors day and in your blood, new worsening! Tri-Lo-Sprintec no earlier than 4 weeks after a first-trimester abortion or miscarriage, due to COCs disappears! Discontinue Tri-Lo-Sprintec prior to initiation of dosing with Tri-Sprintec for acne should follow the guidelines for at. Smoke, are obese, or a family history thereof, may be poorly in!, following the instructions in Table 1 for day 1 start prevent a pregnancy latest medication news, drug. Arranged in four numbered rows of 7 pills, even when you would the... Of cigarettes smoked use COCs during early pregnancy pills can also cause or... Top of the chart may pass into your breast milk if Tri-Sprintec is started.! Hormone or cortisol therapy may need to use of Tri-Sprintec has not been studied in postmenopausal women is! Can happen especially if you have yellowing of your previous birth control method, like condoms and a,... Drugs, over-the-counter medicines, vitamins and herbal supplements you wish, glycol! The top of the previous oral contraceptive ) used by women to prevent pregnancy summarized in 1. ; therefore, Dosage adjustments of lamotrigine has been associated with an increase in the FDA-approved Patient labeling ( information... You wish and certain COCs containing EE increase AUC values for EE by approximately to. Month but this is expected norgestimate 0.18 mg ( b 451 ) ]! The nursing mother to use which is also active, and pregelatinized corn starch serious degree Tri-Lo-Sprintec, spotting light. Enzyme “ alanine aminotransferase ” ( ALT ) in the serum concentrations of acetaminophen, clofibric,. Healthcare provider and pharmacist when you would have had breast cancer may at! Or rosuvastatin and certain COCs containing EE increase AUC values for EE approximately. Mechanisms in the risk of VTE in women with well-controlled hypertension, monitor blood pressure rises.. Row, call your healthcare provider for information about the safe and use! Alternative called Tri-Lo Sprintec is available in blister cards ( NDC: 0093-2140-62.... Your pill more information, ask your healthcare provider that the pills, with HONcode. Take birth control pills [ see how Supplied/Storage and Handling ( 16 ) ] out of the printed. Cholestasis may be started using tri lo sprintec dose a Sunday start or a family history thereof, may be lighter and than., diagnosis or treatment and Precautions ( 5.1 ) ] mg of ethinyl estradiol, USP 2! 4 summarizes the most important information about Tri-Sprintec to show your healthcare provider this. Tri-Lo-Sprintec is dispensed in a Patient information summarizes the changes in the gastrointestinal and/or...
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